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克隆類(lèi)型：	Rat Monoclonal Antibody；Clone number：MF-23
亞　　型：	Rat IgG2b
純化方式：	Concentration：0.2 mg/ml
緩沖液：	PBS pH 7.2, 0.09% NaN3, 0.2% BSA
產(chǎn)品描述：	FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2. The 150D monoclonal antibody reacts with human, mouse and rat FOXP3. The 150D antibody recognizes FOXP3 epitope encoded by exon 2.
適用物種：	Mouse
應(yīng)用范圍：	FC
應(yīng)用說(shuō)明：	The amount of the reagent is suggested to be used ≤ 1.0 μg /10^6 cells in 100 μl
保存條件：	Store at 4°C and protected from prolonged exposure to light. Do not freeze.
標(biāo) 記物：	PE
產(chǎn)品說(shuō)明：

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