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前列腺特異性抗原(PSA)是激肽釋放酶家族的一種絲氨酸蛋白酶，由前列腺上皮和尿道周圍腺體的上皮內(nèi)壁產(chǎn)生。雖然PSA被認為是前列腺特異的，但在乳腺組織、乳腺腫瘤、子宮內(nèi)膜、腎上腺腫瘤和腎細胞癌中也檢測到PSA?？筆SA抗體可用于鑒別高級別前列腺癌和高級別泌尿系上皮癌，也可用于非前列腺組織中前列腺癌起源的判斷?？筆SA抗體可識別原發(fā)和轉(zhuǎn)移性前列腺腫瘤，但不能識別非前列腺來源的腫瘤，可作為確定原發(fā)和轉(zhuǎn)移癌中前列腺腺泡細胞來源的輔助手段。

Prostate-Specific Antigen (PSA) is a serine protease of the kallikrein family, that is produced by the prostate epithelium and epithelial lining of the periurethral glands. Although considered prostate-specific, PSA has also been detected in breast tissue, breast tumors, endometrium, adrenal neoplasms, and renal cell carcinomas. Anti-PSA can be used for differentiating high-grade prostate adenocarcinoma from high-grade urothelial carcinoma, as well as for determining the prostatic origin of carcinomas in non-prostate tissues. Anti-PSA recognizes primary and metastatic prostatic neoplasms, but not tumors of nonprostatic origin, and can be useful as an aid to confirm prostatic acinar cell origin in primary and metastatic carcinomas.

 

Clone： IHC654

Source： Mouse Monoclonal

Positive Control： Prostate, Prostate Carcinoma

Dilution Range: 1:50-1:200

 

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