| 克隆類型 ： |
Rabbit Polyclonal Antibody |
|
亞 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within human Slc35D1. |
|
產(chǎn)品描述 ： |
The solute carrier family Slc35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident Slc family member Slc35D1 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. These molecules can serve as substrates for chondroitin sulfate biosynthesis and mice lacking the Slc35D1 gene developed a lethal form of skeletal dysplasia with severe shortening of limbs and facial structures. Examination of epiphyseal cartilage in these mice revealed a decreased proliferating zone with round chrondrocytes, scarce matrices, and reduced proteoglycan aggregates. Loss of function mutations in human Slc35D1 cause Schneckenbecken dysplasia, a severe skeletal dysplasia. This antibody is predicted to not cross-react with the highly homologous Slc35D2. |
| 適用物種 ： |
H, M, R |
|
應用范圍 ： |
E, WB |
| 應用說明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500 |
| 別 名 ： |
Slc35D1 ; Solute carrier family 35 member D1; UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter |
|
形 態(tài) ： |
Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography. |
| 保存條件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 產(chǎn)品鏈接 ： |
http://www.abbiotec.com/antibodies/slc35d1-antibody-0 |
| 標 記 物 ： |
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產(chǎn)品說明 ： |
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